Collagenase and Tyrosinase Inhibitory Activities and Stability of Facial Cream Formulation Containing Cashew Leaf Extract

The cashew tree (Anacardium occidentale L.) is a tropical plant found widely in many Southeast Asian countries, including Thailand, and contains bioactive phenolic compounds with antioxidant activity. natural antioxidants such as collagenase tyrosinase inhibitors medicinal plants are promising agents cosmetic products. This study evaluated the inhibitory activities of from leaf extracts by developing evaluating stability facial cream formulations. ethanol (DEN), ethyl acetate (DEA) distilled water (DDW) crude leaves were investigated for their compound efficacy. DDW extract had highest yield (24.97%). All activities. DEN showed DPPH radical-scavenging ability, ferric-reducing power flavonoid compounds, which 152.04 ± 2.40 mg gallic acid/g extract, 37.90 1.07 dry weight 7.63 0.07 quercetin/g weight, respectively. exhibited potent activity, was 111.00 0.78 terms content, while inhibition at 0.100 mg/mL (46.97 3.34%) activity 40 µg/mL. results suggested that ethanolic promise use skincare product development. Cosmeceutical formulations prepared. formula mixed added to whitening anti-aging demonstrated good physical properties.